The Ingenuity integration plug-in allows you to uploads genes and expression data directly from the CLC bio analysis to the Ingenuity Pathway Analysis (IPA) tools for downstream biological interpretation.
IPA is a solution that helps researchers model, analyze, and understand complex biological systems by linking incoming data with known information regarding molecular interactions, cellular phenotypes, and disease processes.
The Ingenuity plugin allows direct upload of one or more genes of interest from the CLC bio analysis, or upload of entire datasets from RNA Seq samples, such as the expression levels of all transcripts. In addition, differential expression results from either microarray data or RNA Seq data can be uploaded from the CLC bio tools to IPA.
All or filtered results of the most interesting genes can be uploaded, and one can now study up and down regulation of genes in pathway view in IPA, and identify the most prominent biological processes involved in ones experiment, as well as have access to associated literature.
Analyze and interpret to generate biological insights:
- Canonical Pathways
- Biological Functions
- Mechanical Hypotheses
- Disease mechanisms
Read more about IPA at the Ingenuity web site.
The plugin is easily installed from within the Workbench:
- Click Plugins in the Toolbar
- Click the tab Download Plugins
- Select the plugin you wish to install
- Click the Download and Install button
Download from www.clcbio.com
Alternatively, you can download the plugin.