Adding and editing sequence annotations

Most sequences carry different biological information. When retrieving sequences from various databases, the sequences often contain biological information in the form of annotations.


In CLC Protein Workbench, you can manually add annotations from a compiled annotation list. This list of annotations covers the most used annotations in UniProt and GenBank. Annotations which have been added to a sequence can be removed any time.

The right-hand part of the Add Annotations dialog have the following text fields:

  • Name. The name of the annotation which can be shown in the view. Whether the name is shown depends on the Annotation Layout preferences
  • Chosen type. The type of annotation (e.g. exon)
  • Note. This is a field for entering notes about the annotation. The note will be displayed in a tooltip when you hold the mouse pointer over the sequence.
  • Evidence. There are two options for the evidence supporting the annotation: experimental and non-experimental.
  • Region. If you have already made a selection, this field will show the positions of the selection. You can modify the region further using the syntax of the conventions of DDBJ, EMBL and GenBank.

Note! that the annotation will be included if you export the sequence in GenBank, Swiss-Prot or CLC format.

An existing annotation can be modified through a similar dialogue, except that some of the fields are filled out depending on how much information the annotation contains.

Removing annotations

Annotations can be hidden using the Annotation Types preferences in the View Preferences in the right side of the screen.

Or they can be deleted/removed completely by a simple selection followed by choosing the delete/remove option.