CLC Genomics Machine

 
 
Overview

Genomics Machine

Turnkey solution for large full-genome analyses

CLC Genomics Machine is a turnkey solution including a lightning fast hardware platform with pre-installed enterprise software focusing on high-throughput sequencing data analysis – ready to function straight out of the box.

In addition, CLC Genomics Machine comes with several CLC Genomics Workbenches for user-friendly NGS data analysis on your own desktop computer.

Performance

0h 13m 07sRoche 454-Titanium
Read mapping: Human GRCh37, 2.8 million reads, read length: 569 bp, 1,6 GigaBases
0h 21m 03sIon Torrent
Read mapping: Human GRCh37, 11.6 million reads, read length: 251 bp, 2.89 GigaBases
1h 04m 43sPacBioRs
Read mapping: Human GRCh37, 1.7 million reads, read length: 555 bp, 0.95 GigaBases
17h 12m 59sIllumina GAII (paired)
Read mapping: Human GRCh37, 1.34 billion reads, read length: 100/102 bp, 136 GigaBases


Download our white paper on read mapping

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Overview

Architectonical overview of the turnkey solution CLC Genomics Machine. A powerful three-tier software solution installed ready to plug-and-play together with your CLC Genomics Workbench(es).

The system

Configuration

Backbone of your NGS analyses

This enterprise solution comes pre-installed with our award winning CLC Genomics Server. An advanced and powerful bioinformatics solution which can function as the backbone for an organization’s pipeline for analyzing NGS data.

The server includes

  • A powerful and modern three-tier server architecture
  • Flexible options for executing centralized services
  • Easy integration with other applications and services
  • Powerful database communication and data integration
  • Secure access control framework and central action logging

Server architecture

  • Easy integration with other applications and services
  • Secure access control framework and central action logging
  • Software for client computers (CLC Genomics Workbench) included
  • Three-tier server architecture

NGS cross platform solution

CLC bio offers the first and only comprehensive analysis package which can analyze and visualize data from all major NGS platforms, such as Illumina, SOLiD, Ion Torrent, and HeliScope – as well as Sanger data.

Furthermore the graphical user-clients are platform independent, running on Mac OS X, Windows, and Linux – including 64bit versions.

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The future...

Integration

Future-proof with integration of 3rd party software

With CLC Developer Kit (SDK) it is possible to customize and expand the functionality of a CLC solution on both client-side (CLC Genomics Workbench) and server-side (CLC Genomics Server) in every relevant aspect, giving you the flexibility of creating exactly the bioinformatics solution that you prefer. This makes it a highly future-proof solution, where new requirements appear regularly.

  • Full integration of all your bioinformatics algorithms in one program
  • Development of plugins that integrates all your specialized bioinformatics algorithms
  • Advanced database searches in local and all global databases
  • Storage of bioinformatics data in your own database
  • Graphical and textual viewing of data in any way you want
  • Full IT-support of your workflow

Anybody with knowledge of Java can develop plugins. If you like, you can choose to let our world class bioinformaticists and computer scientist help you in the process, or you can let us do all the development work, based on your requirement specifications.

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The analysis...

Features

CLC Genomics Machine is a turnkey solution providing your organization with a wide range of high-throughput sequencing data analyses. Some of them are:

Genomics

  • Whole genome resequencing and targeted resequencing of genomes of any size and type – from bacteria and vira to humans
  • De novo sequencing of an unlimited number of reads, for genomes up to 50 mega bases
  • SNP/DIP detection and identification of genomic rearrangements
  • Visualization and interactive graphical manipulation of results

Transcriptomics

  • Digital gene expression based on RNA-Seq, including a wide range of downstream gene expression analyses
  • Discovery of novel transcripts/exons
  • Ability to work with expression arrays and RNA-seq results at the same time, enabling comparison of results
  • Tag profiling, including SAGE screen analyses
  • Small RNA analysis
  • Interactive views of assemblies and derived gene expression data

Epigenomics

  • Chromatin immunoprecipitation sequencing (ChIP-seq) analysis
  • Peak finding and peak refinement
  • Graph and table of background distribution and false discovery rate
  • Peak table and annotations

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